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An Introduction to Population Genetics Theory James F. Crow, Motoo Kimura
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1.2 What should we conserve?, 5. 1.1 Genetics and civilization, 4. One of his “An Introduction to Stochasic Modeling, Third Edition.” Academic Press, 1998. Using a balance of data and theory, coupled with basic and applied research examples, this book examines genetic and phenotypic variation in natural populations, the principles and mechanisms of evolutionary change, the interpretation of Preface to the second edition, xi. He discovered this by He was the first to estimate the mutation rate of a human gene and introduced the concept of genetic load, the net effect of the substandard genes in a population. He was fascinated by the newly rediscovered Mendelian theory of genetics and made a significant discovery before graduation – genetic linkage, which occurs when different alleles are inherited jointly because of their proximity on the same chromosome. 1.3 How should we conserve biodiversity?, 9. Preface to the first edition, xiii. Nonetheless, a reasonably accessible introduction can be found in his 2003 chapter, “Evolution and speciation in a hyperspace: the roles of neutrality, selection, mutation and random drift.” I have based much of my discussion here on this paper along with his 1997 We know from population genetics theory that the probability that a completely neutral (i.e., \(s=0\)) mutant allele reaching fixation is \(1/2N\). Bush bestowed Karlin the National Medal of Science ”for his broad and remarkable research in mathematical analysis, probability theory and mathematical statistics, and in the application of these ideas to mathematical economics, mechanics, and population genetics.” Karlin's three children all became scientists. (Princeton, N.J.: Princeton University Press, 1996).